Our Research Group ニューロモデュレーション研究会

About Us

ニューロモデュレーション療法は、電気・磁気・薬物によって神経機能を修飾し、症状を緩和させる治療法です。精神神経科領域では、特に電気・磁気によるモダリティを活用することが一般的です。研究会のミッションは、国内外の企業と連携しながら、アンメットニーズに応じた医療機器およびプログラム医療機器の開発を推進しています。

研究テーマ

• 精神疾患レジストリを活用した磁気けいれん療法の開発に関する研究
• 維持療法の開発と保険収載を目指した先進医療による非無作為化縦断研究
• 双極性障害抑うつエピソードへの新規刺激条件の開発と適応拡大を目指した先進医療による検証的試験に関する研究
• 新規刺激条件の開発と検証的試験に関する研究
• 診療ガイドラインの作成と治療戦略に関する研究
• Virtual Reality技術を活用した新規治療法に関する研究

メンバー

鬼頭伸輔（附属病院）
五十嵐俊（附属病院）
山田洸大（附属病院・大学院生）
垂石七星（柏病院・大学院生）
野田隆政（国立精神・神経医療研究センター）
林大祐（国立精神・神経医療研究センター）
宮谷龍之介（国立精神・神経医療研究センター）
熊谷航一郎（国立精神・神経医療研究センター・大学院生）

主要な研究論文

研究論文

1. Morishita T, Kito S, Yamashiro K, Konno D, Arima H, Abe H, Iwasaki M: Japanese psychiatrists’ perceptions of surgical treatment for treatment-resistant obsessive compulsive disorder: A nationwide survey. PCN Rep 5: e70345, 2026.
2. Igarashi S, Matsuda Y, Hayashi D, Taruishi N, Yamazaki R, Mori K, Kumagai K, Kodaka F, Noda T, Watanabe K, Kito S: Discrepancy Between Subjective and Objective Assessments Focusing on Item-level Symptom Improvement in Repetitive Transcranial Magnetic Stimulation Therapy for Treatment-resistant Depression: A Two-site Prospective Study. Psychiatry Res 352: 116682, 2025.
3. Igarashi S, Tsuboi T, Hasegawa N, Ochi S, Ohi K, Fukumoto K, Iga J, Muraoka H, Iida H, Kodaka F, Numata S, Ichihashi K, Kashiwagi H, Nakamura T, Yamagata H, Takeshima M, Nagasawa T, Matsumoto J, Yamada H, Hori H, Inada K, Yasui-Furukori N, Hashimoto R, Watanabe K: Maintenance pharmacotherapy after electroconvulsive therapy in inpatients with major depressive disorder: 198 prescriptions in a real-world clinical setting. BMC Psychiatry 25: 957, 2025.
4. Noda T, Nishikawa M, Matsuda Y, Hayashi D, Kito S: Efficacy and safety of low-frequency repetitive transcranial magnetic stimulation for bipolar depression: a study protocol for a multicenter, double-blind, randomized, sham-controlled trial. Front Psychiatry 16: 1393605, 2025.
5. Kishi T, Sakuma K, Hamanaka S, Nishii Y, Esaki K, Zhao Y, Matsuda Y, Kito S, Iwata N: Accelerated intermittent theta burst stimulation for pharmacological treatment-resistant bipolar depression: Protocol for double-blind, randomized, sham-controlled trial. PCN Rep 4: e70064, 2025.
6. Nakazawa A, Matsuda Y, Yamazaki R, Taruishi N, Kito S: Effects of repetitive transcranial magnetic stimulation therapy on weight and lipid metabolism in patients with treatment-resistant depression: A preliminary single-center retrospective cohort study. Neuropsychopharmacol Rep 45: e12494, 2025.
7. Matsuda Y, Kito S, Hiraki F, Izuno T, Yoshida K, Nakamura M, Kodaka F, Yamazaki R, Taruishi N, Imazu S, Kanazawa T, Mekata T, Moriyama S, Wada M, Nakajima S, Sawada K, Watanabe S, Takahashi S, Toi Y, Hayashi D, Igarashi S, Fujiyama K, Ikeda S, Tateishi H, Kojima R, Sato K, Boku S, Takebayashi M, Ogura M, Takaya A, Endo K, Kita A, Arai H, Kamimura H, Matsuo K, Denda K, Yamashiro S, Yoshioka D, Kizaki J, Mimura M, Noda Y: A multisite observational real-world study on the effectiveness of repetitive transcranial magnetic stimulation therapy for patients with treatment-resistant depression in Japan. Psychiatry Res 342: 116263, 2024.
8. Kishi T, Ikuta T, Sakuma K, Hamanaka S, Nishii Y, Hatano M, Kito S, Iwata N: Theta burst stimulation protocols for schizophrenia: A systematic review and network meta-analysis. JAMA Netw Open 7: e2441159, 2024.
9. Hayashi D, Yamazaki R, Matsuda Y, Igarashi S, Taruishi N, Kodaka F, Shigeta M, Kito S: Association between stimulation-site pain and clinical improvement during repetitive transcranial magnetic stimulation for patients with major depressive disorders: a prospective observational study at two sites. Neuropsychobiology 83: 152-159, 2024.
10. Kishi T, Ikuta T, Sakuma K, Hatano M, Matsuda Y, Wilkening J, Goya-Maldonado R, Tik M, Williams NR, Kito S, Iwata N: Theta burst stimulation for depression: a systematic review and network and pairwise meta-analysis. Mol Psychiatry 29: 3893-3899, 2024.

総説・症例報告等

1. Kitagawa Y, Igarashi S, Kawaguchi K, Kito S: Successful Electroconvulsive Therapy for Treatment-Resistant Depression Following Traumatic Brain Injury: A Case Report. J ECT. (In press).
2. Matsuda Y, Sakuma K, Igarashi S, Hayashi D, Kito S, Kishi T: Neuromodulation Therapies for Depression: Current Status and Future Directions. Alpha Psy. (In press).
3. Igarashi S, Nakakoji T, Kusunoki Nakamoto F, Kumagai K, Namatame S, Kubota M, Hayashi D, Noda T, Kito S: Electroconvulsive Therapy for Catatonia in Primary Brain Calcification: A Case Report. J ECT. (Publish Ahead of Print), 2026.
4. Kawaguchi K, Ishii K, Kito S: Prophylactic Acetaminophen Prevented Severe Post-Electroconvulsive Therapy Headaches and Enabled Therapy Completion: A Case Report. J ECT. (Publish Ahead of Print), 2026.
5. Igarashi S, Hashimoto H, Miyazaki T, Takizawa H, Hayashi D, Nagao K, Kumagai K, Watanabe K, Noda T, Kito S: Electroconvulsive Therapy for Catatonia in a Patient with Schizophrenia Comorbid with Becker Muscular Dystrophy: A Case Report. J ECT 41(4): e60-e61, 2025.
6. Igarashi S, Okita K, Hayashi D, Yamazaki R, Matsuda Y, Noda T, Watanabe K, Kito S*: Neuroinflammatory Alterations in Treatment-Resistant Depression Secondary to Long COVID by Repetitive Transcranial Magnetic Stimulation (rTMS): A Case Report. Psychiatr Res Clin Pract 6(2): 63-64, 2024.